Palmitoylethanolamide (PEA) is a bio-identical acid amide synthesized by healthy tissue in response to inflammation. PEA has been scientifically shown to act as a Peroxisome Proliferator Alpha (PPA) agonist and naturally possesses anti-inflammatory, neuro-protective and anti-nociceptive (pain control) properties. This natural anti-inflammatory supports the nervous system and normalizes immune responses.*

As a non-psychoactive indirect endocannabinoid, PEA does not block pain signals like opioids or other analgesics but instead enhances the G protein sensitivity of the CB2 receptor. The main effect is elicited by stabilization of microglial and mast cells' function, as supported by numerous studies. Microglial cells are crucial to the nervous system and can exert inflammatory responses on neurons. Mast cells are immune system cells that respond to chemical signals from tissue injury.