Do these mount at the same points as the factory lights?

Yes. These use factory mounting points with no drilling or bracket modification needed. Unbolt the stock lights, bolt these on, plug in the harness connector, and you're done.

Will these work with my truck's existing wiring?

They're designed to use the factory tail light connector. If your truck is bone stock, the plug matches directly. If you've already modified your wiring, test the fit and polarity before final installation.

Do I need to do anything to the lens before installing?

No prep needed on your end. The lenses come ready to mount. Make sure the body panels are clean and dry where the lights seat to avoid trapped moisture.